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Isotretinoin, INN, /ˌaɪsoʊtrɨˈtɪnoʊ.ɨn/,[1] (also known as 13-cis retinoic acid) first marketed as Accutane by Hoffmann-La Roche, is a medication primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and can be used in the treatment of brain,[2] pancreatic and other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body.
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